%PDF-1.7
%
1 0 obj
<<
/FICL#3AEnfocus 2 0 R
/PageMode /UseThumbs
/CP2 3 0 R
/Metadata 4 0 R
/AcroForm 5 0 R
/Pages 6 0 R
/PageLayout /SinglePage
/OpenAction 7 0 R
/Type /Catalog
/PageLabels 8 0 R
>>
endobj
9 0 obj
<<
/CrossMarkDomains#5B2#5D (elsevier.com)
/CreationDate (D:20140303070244+08'00')
/CrossmarkMajorVersionDate (2010-04-23)
/Subject (Neoplasia, 14 \(2012\) 732-741. doi:10.1593/neo.12858)
/Author (Lu Jiang)
/Creator (Elsevier)
/ElsevierWebPDFSpecifications (6.4)
/CrossmarkDomainExclusive (true)
/robots (noindex)
/ModDate (D:20140303070318+08'00')
/doi (10.1593/neo.12858)
/CrossMarkDomains#5B1#5D (sciencedirect.com)
/Title (Localized Hypoxia Results in Spatially Heterogeneous Metabolic Signatures in Breast Tumor Models)
/Trapped /False
>>
endobj
2 0 obj
<<
/CertifiedWF 10 0 R
>>
endobj
3 0 obj
<<
/PrivateDataFilter [/FlateDecode]
>>
endobj
4 0 obj
<<
/Length 6684
/Subtype /XML
/Type /Metadata
>>
stream
application/pdf
doi:10.1593/neo.12858
Localized Hypoxia Results in Spatially Heterogeneous Metabolic Signatures in Breast Tumor Models
Lu Jiang
Tiffany R. Greenwood
Dmitri Artemov
Venu Raman
Paul T. Winnard Jr
Ron M.A. Heeren
Zaver M. Bhujwalla
Kristine Glunde
Neoplasia, 14 (2012) 732-741. doi:10.1593/neo.12858
Neoplasia Press, Inc
journal
Neoplasia
Copyright © 2012 Neoplasia Press, Inc. All rights reserved
1476-5586
14
8
August 2012
732-741
732
741
10.1593/neo.12858
http://dx.doi.org/10.1593/neo.12858
2010-04-23
true
10.1593/neo.12858
elsevier.com
sciencedirect.com
6.4
10.1593/neo.12858
noindex
2010-04-23
true
sciencedirect.com
elsevier.com
Elsevier
2014-03-03T07:03:18+08:00
2014-03-03T07:02:44+08:00
2014-03-03T07:03:18+08:00
True
False
uuid:f0caed57-dfe3-445f-b6a6-89882ac614fd
uuid:5972cf08-14df-4bc5-85bd-df08d86bb798
endstream
endobj
5 0 obj
<<
/Fields []
/DA (/Helv 0 Tf 0 g )
/DR <<
/Font <<
/Helv 11 0 R
/ZaDb 12 0 R
>>
/Encoding <<
/PDFDocEncoding 13 0 R
>>
>>
>>
endobj
6 0 obj
<<
/Count 10
/Type /Pages
/Kids [14 0 R 15 0 R 16 0 R 17 0 R 18 0 R 19 0 R 20 0 R 21 0 R 22 0 R 23 0 R]
>>
endobj
7 0 obj
<<
/D [14 0 R /FitH -32768]
/S /GoTo
>>
endobj
8 0 obj
<<
/Nums [0 24 0 R]
>>
endobj
10 0 obj
<<
/Version 1
/Sessions [25 0 R]
/Stamp [35 210 220 245 37 217 251 25 49 197
222 128 0 19 89 154 152 48 173 190]
>>
endobj
11 0 obj
<<
/Subtype /Type1
/Name /Helv
/BaseFont /Helvetica
/Encoding 13 0 R
/Type /Font
>>
endobj
12 0 obj
<<
/Subtype /Type1
/Name /ZaDb
/BaseFont /ZapfDingbats
/Type /Font
>>
endobj
13 0 obj
<<
/Differences [24 /breve /caron /circumflex /dotaccent /hungarumlaut /ogonek /ring /tilde 39
/quotesingle 96 /grave 128 /bullet /dagger /daggerdbl /ellipsis /emdash /endash
/florin /fraction /guilsinglleft /guilsinglright /minus /perthousand /quotedblbase /quotedblleft /quotedblright /quoteleft
/quoteright /quotesinglbase /trademark /fi /fl /Lslash /OE /Scaron /Ydieresis /Zcaron
/dotlessi /lslash /oe /scaron /zcaron 160 /Euro 164 /currency 166
/brokenbar 168 /dieresis /copyright /ordfeminine 172 /logicalnot /.notdef /registered /macron
/degree /plusminus /twosuperior /threesuperior /acute /mu 183 /periodcentered /cedilla /onesuperior
/ordmasculine 188 /onequarter /onehalf /threequarters 192 /Agrave /Aacute /Acircumflex /Atilde
/Adieresis /Aring /AE /Ccedilla /Egrave /Eacute /Ecircumflex /Edieresis /Igrave /Iacute
/Icircumflex /Idieresis /Eth /Ntilde /Ograve /Oacute /Ocircumflex /Otilde /Odieresis /multiply
/Oslash /Ugrave /Uacute /Ucircumflex /Udieresis /Yacute /Thorn /germandbls /agrave /aacute
/acircumflex /atilde /adieresis /aring /ae /ccedilla /egrave /eacute /ecircumflex /edieresis
/igrave /iacute /icircumflex /idieresis /eth /ntilde /ograve /oacute /ocircumflex /otilde
/odieresis /divide /oslash /ugrave /uacute /ucircumflex /udieresis /yacute /thorn /ydieresis]
/Type /Encoding
>>
endobj
14 0 obj
<<
/CropBox [0 0 612 792]
/Parent 6 0 R
/Contents [26 0 R 27 0 R 28 0 R 29 0 R 30 0 R 31 0 R 32 0 R 33 0 R 34 0 R 35 0 R]
/Rotate 0
/MediaBox [0 0 612 792]
/Resources <<
/ColorSpace <<
/CS0 [/Separation /Black /DeviceCMYK 36 0 R]
>>
/Font <<
/T1_10 37 0 R
/T1_11 38 0 R
/T1_0 39 0 R
/T1_1 40 0 R
/T1_2 41 0 R
/T1_3 42 0 R
/T1_4 43 0 R
/T1_5 44 0 R
/T1_6 45 0 R
/T1_7 46 0 R
/T1_8 47 0 R
/T1_9 48 0 R
/F13 49 0 R
/F14 50 0 R
/F15 51 0 R
>>
/ProcSet [/PDF /Text]
/ExtGState <<
/GS0 52 0 R
/GS1 53 0 R
/GS2 54 0 R
>>
/XObject <<
/Im1 55 0 R
>>
>>
/Type /Page
/Annots [56 0 R]
>>
endobj
15 0 obj
<<
/CropBox [0 0 612 792]
/Parent 6 0 R
/Contents 57 0 R
/Rotate 0
/MediaBox [0 0 612 792]
/Resources <<
/Font <<
/T1_0 44 0 R
/T1_1 47 0 R
/T1_2 58 0 R
/T1_3 59 0 R
/T1_4 60 0 R
/T1_5 61 0 R
/T1_6 40 0 R
/T1_7 48 0 R
/T1_8 38 0 R
>>
/ProcSet [/PDF /Text]
/ExtGState <<
/GS0 62 0 R
/GS1 63 0 R
>>
>>
/Type /Page
>>
endobj
16 0 obj
<<
/CropBox [0 0 612 792]
/Parent 6 0 R
/Contents 64 0 R
/Rotate 0
/MediaBox [0 0 612 792]
/Resources <<
/Font <<
/T1_0 47 0 R
/T1_1 61 0 R
/T1_2 65 0 R
/T1_3 59 0 R
/T1_4 66 0 R
/T1_5 60 0 R
/T1_6 38 0 R
/T1_7 48 0 R
/T1_8 40 0 R
>>
/ProcSet [/PDF /Text]
/ExtGState <<
/GS0 62 0 R
/GS1 63 0 R
>>
>>
/Type /Page
>>
endobj
17 0 obj
<<
/CropBox [0 0 612 792]
/Parent 6 0 R
/Contents 67 0 R
/Rotate 0
/MediaBox [0 0 612 792]
/Resources <<
/XObject <<
/Im0 68 0 R
/Im1 69 0 R
>>
/Font <<
/T1_0 40 0 R
/T1_1 42 0 R
/T1_2 70 0 R
/T1_3 48 0 R
/T1_4 38 0 R
>>
/ProcSet [/PDF /Text /ImageC]
/ExtGState <<
/GS0 52 0 R
/GS1 62 0 R
>>
>>
/Type /Page
>>
endobj
18 0 obj
<<
/CropBox [0 0 612 792]
/Parent 6 0 R
/Contents 71 0 R
/Rotate 0
/MediaBox [0 0 612 792]
/Resources <<
/XObject <<
/Im0 72 0 R
>>
/Font <<
/T1_0 47 0 R
/T1_1 61 0 R
/T1_2 59 0 R
/T1_3 40 0 R
/T1_4 42 0 R
/T1_5 38 0 R
/T1_6 48 0 R
>>
/ProcSet [/PDF /Text /ImageC]
/ExtGState <<
/GS0 62 0 R
/GS1 63 0 R
>>
>>
/Type /Page
>>
endobj
19 0 obj
<<
/CropBox [0 0 612 792]
/Parent 6 0 R
/Contents 73 0 R
/Rotate 0
/MediaBox [0 0 612 792]
/Resources <<
/XObject <<
/Im0 74 0 R
>>
/Font <<
/T1_10 38 0 R
/T1_0 47 0 R
/T1_1 58 0 R
/T1_2 59 0 R
/T1_3 60 0 R
/T1_4 61 0 R
/T1_5 44 0 R
/T1_6 40 0 R
/T1_7 42 0 R
/T1_8 45 0 R
/T1_9 48 0 R
>>
/ProcSet [/PDF /Text /ImageB]
/ExtGState <<
/GS0 62 0 R
/GS1 63 0 R
>>
>>
/Type /Page
>>
endobj
20 0 obj
<<
/CropBox [0 0 612 792]
/Parent 6 0 R
/Contents 75 0 R
/Rotate 0
/MediaBox [0 0 612 792]
/Resources <<
/XObject <<
/Im0 76 0 R
>>
/Font <<
/T1_0 47 0 R
/T1_1 59 0 R
/T1_2 40 0 R
/T1_3 42 0 R
/T1_4 45 0 R
/T1_5 38 0 R
/T1_6 48 0 R
>>
/ProcSet [/PDF /Text /ImageB]
/ExtGState <<
/GS0 62 0 R
/GS1 63 0 R
>>
>>
/Type /Page
>>
endobj
21 0 obj
<<
/CropBox [0 0 612 792]
/Parent 6 0 R
/Contents 77 0 R
/Rotate 0
/MediaBox [0 0 612 792]
/Resources <<
/XObject <<
/Im0 78 0 R
>>
/Font <<
/T1_10 38 0 R
/T1_0 47 0 R
/T1_1 59 0 R
/T1_2 58 0 R
/T1_3 44 0 R
/T1_4 60 0 R
/T1_5 40 0 R
/T1_6 42 0 R
/T1_7 45 0 R
/T1_8 43 0 R
/T1_9 48 0 R
>>
/ProcSet [/PDF /Text /ImageC]
/ExtGState <<
/GS0 62 0 R
/GS1 63 0 R
>>
>>
/Type /Page
>>
endobj
22 0 obj
<<
/CropBox [0 0 612 792]
/Parent 6 0 R
/Contents 79 0 R
/Rotate 0
/MediaBox [0 0 612 792]
/Resources <<
/Font <<
/T1_0 47 0 R
/T1_1 58 0 R
/T1_2 59 0 R
/T1_3 44 0 R
/T1_4 80 0 R
/T1_5 60 0 R
/T1_6 38 0 R
/T1_7 48 0 R
/T1_8 40 0 R
>>
/ProcSet [/PDF /Text]
/ExtGState <<
/GS0 62 0 R
/GS1 63 0 R
>>
>>
/Type /Page
>>
endobj
23 0 obj
<<
/CropBox [0 0 612 792]
/Parent 6 0 R
/Contents 81 0 R
/Rotate 0
/MediaBox [0 0 612 792]
/Resources <<
/Font <<
/T1_0 47 0 R
/T1_1 59 0 R
/T1_2 80 0 R
/T1_3 58 0 R
/T1_4 60 0 R
/T1_5 40 0 R
/T1_6 48 0 R
/T1_7 38 0 R
>>
/ProcSet [/PDF /Text]
/ExtGState <<
/GS0 62 0 R
/GS1 63 0 R
>>
>>
/Type /Page
>>
endobj
24 0 obj
<<
/St 732
/S /D
>>
endobj
25 0 obj
<<
/Length 14316
/Version 1
/Filter /FlateDecode
/Stamp
>>
stream
HW{TnZ*HL:Y%B- "a2;3FFc}&&&Fjbchj4I4F+E爱,J<=09[ԸFq3a!8!|Du9b(BN9E@-p;01
Ώ6E\,M,I»݀#P+OgʔgX9w"K