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Waleed F. Janem, Frank A. Scannapieco, Amarpeet Sabharwal, Maria Tsompana, Harvey A. Berman, Elaine M. Haase, Jeffrey C. Miecznikowski, Lucy D. Mastrandrea
Salivary inflammatory markers and microbiome in normoglycemic lean and obese children compared to obese children with type 2 diabetes
www.plosone.org
www.plosone.org
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1.0999 0 Td
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3.2314 0 Td
(released)Tj
3.4299 0 Td
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1.8425 0 Td
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(from)Tj
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(epithelial)Tj
3.8721 0 Td
(and)Tj
1.7291 0 Td
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5.709 0 Td
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(crevicular)Tj
4.1669 0 Td
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1.9275 0 Td
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5.777 0 Td
(biomarkers)Tj
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(that)Tj
1.7801 0 Td
(have)Tj
2.058 0 Td
(been)Tj
2.1259 0 Td
(found)Tj
2.6192 0 Td
(to)Tj
1.0262 0 Td
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-35.8807 -1.2983 Td
(elevated)Tj
3.4525 0 Td
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(individuals)Tj
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2.0013 0 Td
(T2D)Tj
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1.7291 0 Td
(periodontal)Tj
4.8699 0 Td
(disease)Tj
3.0161 0 Td
(include)Tj
3.1861 0 Td
(interleukin)Tj
-33.1311 -1.3039 Td
(1-)Tj
/F13 1 Tf
()Tj
/F6 1 Tf
1.5306 0 Td
(\(IL-1)Tj
/F13 1 Tf
()Tj
/F6 1 Tf
(\))Tj
3.0898 0 Td
(and)Tj
1.7291 0 Td
(C-reactive)Tj
4.3313 0 Td
(protein)Tj
3.1521 0 Td
(\(CRP\))Tj
2.744 0 Td
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0.83 0.64 0.02 0 k
(22)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(24)Tj
0 g
(].)Tj
3.5489 0 Td
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1.338 0 Td
(our)Tj
1.627 0 Td
(knowledge,)Tj
4.7622 0 Td
(there)Tj
2.2677 0 Td
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1.4457 0 Td
(no)Tj
1.2755 0 Td
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-32.8419 -1.2983 Td
(studies)Tj
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1.0148 0 Td
(salivary)Tj
3.2429 0 Td
(biomarkers)Tj
4.7735 0 Td
(and)Tj
1.7348 0 Td
(the)Tj
1.4683 0 Td
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1.7801 0 Td
(microbiome)Tj
5.1307 0 Td
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1.0375 0 Td
(adolescents)Tj
4.7735 0 Td
(with)Tj
1.9956 0 Td
(and)Tj
1.7291 0 Td
(without)Tj
3.3335 0 Td
(T2D.)Tj
-35.0019 -1.2983 Td
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1.627 0 Td
(effective)Tj
3.5093 0 Td
(preventive)Tj
4.3993 0 Td
(care)Tj
1.8766 0 Td
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1.0318 0 Td
(T2D)Tj
2.0466 0 Td
(adolescent)Tj
4.4106 0 Td
(patients,)Tj
3.5944 0 Td
(accurate)Tj
3.5546 0 Td
(understanding)Tj
6.0718 0 Td
(of)Tj
1.0147 0 Td
(the)Tj
1.4684 0 Td
(oral)Tj
-34.6051 -1.3039 Td
(immuno-microbiologic)Tj
9.6377 0 Td
(state)Tj
2.0352 0 Td
(and)Tj
1.7292 0 Td
(early)Tj
2.1486 0 Td
(diagnosis)Tj
3.9628 0 Td
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0.8447 0 Td
(essential.)Tj
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1.9842 0 Td
(study)Tj
2.3925 0 Td
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3.9628 0 Td
(the)Tj
1.4683 0 Td
(oral)Tj
-33.9758 -1.2982 Td
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2.9026 0 Td
(salivary)Tj
3.2428 0 Td
(biomarkers,)Tj
5.0003 0 Td
(and)Tj
1.7348 0 Td
(the)Tj
1.4683 0 Td
(oral)Tj
1.7802 0 Td
(microbiome)Tj
5.1307 0 Td
(of)Tj
1.0148 0 Td
(obese)Tj
2.4434 0 Td
(children)Tj
3.5546 0 Td
(with)Tj
1.9956 0 Td
(normal)Tj
3.1464 0 Td
(and)Tj
-33.4145 -1.2983 Td
(abnormal)Tj
4.0875 0 Td
(glucose)Tj
3.1748 0 Td
(tolerance.)Tj
4.1215 0 Td
(We)Tj
1.6044 0 Td
(hypothesized)Tj
5.4708 0 Td
(that)Tj
1.7802 0 Td
(children)Tj
3.5546 0 Td
(with)Tj
1.9956 0 Td
(T2D)Tj
2.0466 0 Td
(have)Tj
2.0579 0 Td
(higher)Tj
2.8006 0 Td
(rates)Tj
2.109 0 Td
(of)Tj
1.0148 0 Td
(gin-)Tj
-35.8183 -1.3039 Td
(givitis)Tj
2.5965 0 Td
(\(a)Tj
0.9978 0 Td
(pre-periodontal)Tj
6.5309 0 Td
(condition\),)Tj
4.6772 0 Td
(elevated)Tj
3.4526 0 Td
(salivary)Tj
3.2428 0 Td
(inflammatory)Tj
5.7089 0 Td
(markers,)Tj
3.7247 0 Td
(and)Tj
1.7291 0 Td
(an)Tj
1.2019 0 Td
(altered)Tj
-33.8624 -1.2983 Td
(salivary)Tj
3.2428 0 Td
(microbiome)Tj
5.1306 0 Td
(compared)Tj
4.2463 0 Td
(to)Tj
1.0261 0 Td
(children)Tj
3.5547 0 Td
(without)Tj
3.3278 0 Td
(T2D.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 485.0645 cm
BT
/F2 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Materials)Tj
4.5071 0 Td
(and)Tj
1.989 0 Td
(methods)Tj
/F0 1 Tf
-6.4961 -1.5023 Td
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2.7543 0 Td
(population)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 450.0283 cm
BT
/F6 1 Tf
1 TL
-0.01 Tc
0 0 Td
(This)Tj
1.9615 0 Td
(cross-sectional)Tj
6.0151 0 Td
(study)Tj
2.3584 0 Td
(was)Tj
1.6781 0 Td
(approved)Tj
3.9288 0 Td
(by)Tj
1.1679 0 Td
(the)Tj
1.4513 0 Td
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3.7474 0 Td
(and)Tj
1.7121 0 Td
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3.2485 0 Td
(Institutional)Tj
5.0853 0 Td
(Review)Tj
-32.3544 -1.2982 Td
(Board)Tj
2.6078 0 Td
(a)Tj
0.6463 0 Td
(University)Tj
4.3427 0 Td
(at)Tj
0.941 0 Td
(Buffalo)Tj
3.0501 0 Td
(and)Tj
1.7121 0 Td
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1.6838 0 Td
(conducted)Tj
4.371 0 Td
(in)Tj
1.0261 0 Td
(accordance)Tj
4.6772 0 Td
(with)Tj
1.9729 0 Td
(the)Tj
1.4513 0 Td
(Helsinki)Tj
3.5489 0 Td
(Declaration.)Tj
-32.0312 -1.2983 Td
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3.4469 0 Td
(were)Tj
2.0976 0 Td
(recruited)Tj
3.7984 0 Td
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2.1826 0 Td
(the)Tj
1.4514 0 Td
(Diabetes)Tj
3.6226 0 Td
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2.914 0 Td
(and)Tj
1.7121 0 Td
(Endocrine)Tj
4.354 0 Td
(Clinics)Tj
2.9537 0 Td
(at)Tj
0.9411 0 Td
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3.4526 0 Td
(and)Tj
1.7121 0 Td
(Chil-)Tj
-34.6391 -1.3039 Td
(dren's)Tj
2.6305 0 Td
(Hospital)Tj
3.5716 0 Td
(of)Tj
1.0035 0 Td
(Buffalo)Tj
3.0444 0 Td
(over)Tj
1.9559 0 Td
(a)Tj
0.6463 0 Td
(period)Tj
2.8006 0 Td
(of)Tj
0.9978 0 Td
(two)Tj
1.6951 0 Td
(years)Tj
2.2336 0 Td
(\(Feb)Tj
1.9956 0 Td
(2013)Tj
2.0977 0 Td
(to)Tj
1.0147 0 Td
(Feb)Tj
1.6611 0 Td
(2015\).)Tj
2.6476 0 Td
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1.7688 0 Td
(subject's)Tj
3.5376 0 Td
(par-)Tj
-35.3024 -1.2983 Td
(ent/guardian)Tj
5.3234 0 Td
(provided)Tj
3.77 0 Td
(signed)Tj
2.7723 0 Td
(informed)Tj
3.9288 0 Td
(consent)Tj
3.2882 0 Td
(with)Tj
1.9729 0 Td
(assent)Tj
2.6078 0 Td
(or)Tj
1.0885 0 Td
(consent)Tj
3.2882 0 Td
(provided)Tj
3.77 0 Td
(by)Tj
1.1679 0 Td
(the)Tj
1.4513 0 Td
(subject.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 370.7149 cm
BT
/F0 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Inclusion)Tj
4.1102 0 Td
(criteria)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 353.707 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(Male)Tj
2.211 0 Td
(and)Tj
1.7234 0 Td
(female)Tj
2.846 0 Td
(children)Tj
3.5489 0 Td
(1019)Tj
2.6306 0 Td
(years)Tj
2.262 0 Td
(of)Tj
1.0035 0 Td
(age)Tj
1.5363 0 Td
(of)Tj
1.0092 0 Td
(all)Tj
1.1395 0 Td
(racial)Tj
2.3867 0 Td
(and)Tj
1.7235 0 Td
(ethnic)Tj
2.7042 0 Td
(groups)Tj
2.965 0 Td
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3.9288 0 Td
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-35.7333 -1.2982 Td
(jects)Tj
1.9842 0 Td
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1.9956 0 Td
(body)Tj
2.2166 0 Td
(mass)Tj
2.194 0 Td
(index)Tj
2.4548 0 Td
(\(BMI\))Tj
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0 Tc
2.7099 0 Td
()Tj
/F6 1 Tf
-0.004 Tc
0.9922 0 Td
(85)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 355.011 345.1464 cm
BT
/F6 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(th)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 361.1905 340.7244 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(%)Tj
0.9751 0 Td
(for)Tj
1.3889 0 Td
(age)Tj
1.5421 0 Td
(and)Tj
1.7291 0 Td
(gender)Tj
2.982 0 Td
(\(normal)Tj
3.4866 0 Td
(weight\))Tj
3.2258 0 Td
(were)Tj
2.1203 0 Td
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-33.5675 -1.3039 Td
(in)Tj
1.0318 0 Td
(the)Tj
1.474 0 Td
(control)Tj
3.1181 0 Td
(group)Tj
2.6078 0 Td
(\(C\),)Tj
1.7915 0 Td
(subjects)Tj
3.3789 0 Td
(with)Tj
1.9956 0 Td
(BMI)Tj
/F14 1 Tf
0 Tc
2.0351 0 Td
()Tj
/F6 1 Tf
-0.004 Tc
0.9921 0 Td
(95)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 393.7322 332.1637 cm
BT
/F6 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(th)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 399.9118 327.685 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(%)Tj
0.9807 0 Td
(for)Tj
1.3833 0 Td
(age)Tj
1.5421 0 Td
(and)Tj
1.7348 0 Td
(gender)Tj
2.9763 0 Td
(without)Tj
3.3335 0 Td
(T2D)Tj
2.041 0 Td
(were)Tj
-33.9814 -1.2982 Td
(included)Tj
3.7133 0 Td
(in)Tj
1.0318 0 Td
(the)Tj
1.4684 0 Td
(obese)Tj
2.4434 0 Td
(group)Tj
2.6079 0 Td
(\(Ob\),)Tj
2.3811 0 Td
(and)Tj
1.7291 0 Td
(subjects)Tj
3.3789 0 Td
(with)Tj
1.9954 0 Td
(BMI)Tj
/F14 1 Tf
0 Tc
2.0353 0 Td
()Tj
/F6 1 Tf
-0.004 Tc
0.9921 0 Td
(95)Tj
ET
Q
q
1 j
1 J
0 w
7.4999 0 0 6.6659 447.307 319.1244 cm
BT
/F6 1 Tf
1 TL
-0.0053 Tc
0 0 Td
(th)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 453.4866 314.7023 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(%)Tj
0.9751 0 Td
(for)Tj
1.3833 0 Td
(age)Tj
1.5477 0 Td
(and)Tj
1.7291 0 Td
(gender)Tj
2.9763 0 Td
(with)Tj
-33.9587 -1.2982 Td
(diagnosis)Tj
3.9571 0 Td
(of)Tj
1.0148 0 Td
(T2D)Tj
2.041 0 Td
(were)Tj
2.1259 0 Td
(included)Tj
3.7134 0 Td
(in)Tj
1.0318 0 Td
(the)Tj
1.4684 0 Td
(diabetes)Tj
3.4639 0 Td
(group)Tj
2.6078 0 Td
(\(T2D\).)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 274.337 cm
BT
/F0 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Exclusion)Tj
4.4457 0 Td
(criteria)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 257.3291 cm
BT
/F6 1 Tf
1 TL
-0.004 Tc
0 0 Td
(Individuals)Tj
4.7224 0 Td
(with)Tj
1.9956 0 Td
(antibody-positive)Tj
7.2113 0 Td
(diabetes)Tj
3.4639 0 Td
(consistent)Tj
4.252 0 Td
(with)Tj
2.0012 0 Td
(T1D,)Tj
2.2677 0 Td
(steroid-induced)Tj
6.5707 0 Td
(or)Tj
1.0998 0 Td
(cystic)Tj
-33.5846 -1.2982 Td
(fibrosis-related)Tj
6.2248 0 Td
(diabetes,)Tj
3.685 0 Td
(antibody-negative)Tj
7.4324 0 Td
(diabetes)Tj
3.4582 0 Td
(consistent)Tj
4.2577 0 Td
(with)Tj
1.9955 0 Td
(Monogenic)Tj
4.8076 0 Td
(Diabetes)Tj
3.668 0 Td
(of)Tj
-35.5292 -1.2983 Td
(Youth)Tj
2.7099 0 Td
(\(MODY\),)Tj
4.1328 0 Td
(and)Tj
1.7348 0 Td
(chronic)Tj
3.2882 0 Td
(inflammatory)Tj
5.7089 0 Td
(diseases)Tj
3.3732 0 Td
(were)Tj
2.126 0 Td
(excluded.)Tj
4.0082 0 Td
(We)Tj
1.6101 0 Td
(also)Tj
1.7688 0 Td
(excluded)Tj
3.787 0 Td
(individ-)Tj
-34.2479 -1.3039 Td
(uals)Tj
1.7858 0 Td
(who)Tj
1.9389 0 Td
(used)Tj
2.0636 0 Td
(daily)Tj
2.1486 0 Td
(ibuprofen)Tj
4.1782 0 Td
(or)Tj
1.0942 0 Td
(aspirin,)Tj
3.2145 0 Td
(oral)Tj
1.7801 0 Td
(or)Tj
1.0942 0 Td
(inhaled)Tj
3.1975 0 Td
(glucocorticoids,)Tj
6.565 0 Td
(antibiotics)Tj
4.3993 0 Td
(with)Tj
2.0012 0 Td
(the)Tj
-35.4611 -1.2983 Td
(last)Tj
1.559 0 Td
(3)Tj
0.6973 0 Td
(months,)Tj
3.5036 0 Td
(or)Tj
1.0998 0 Td
(atypical)Tj
3.2939 0 Td
(anti-psychotic)Tj
5.9017 0 Td
(drugs.)Tj
2.6985 0 Td
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4.7225 0 Td
(were)Tj
2.1203 0 Td
(not)Tj
1.5761 0 Td
(included)Tj
3.7077 0 Td
(if)Tj
0.7767 0 Td
(they)Tj
1.9219 0 Td
(had)Tj
1.7121 0 Td
(a)Tj
0.6519 0 Td
(his-)Tj
-35.943 -1.2982 Td
(tory)Tj
1.8481 0 Td
(of)Tj
1.0148 0 Td
(rheumatic)Tj
4.3143 0 Td
(fever,)Tj
2.4095 0 Td
(required)Tj
3.634 0 Td
(antibiotic)Tj
4.0421 0 Td
(prophylaxis)Tj
4.8869 0 Td
(prior)Tj
2.2564 0 Td
(to)Tj
1.0205 0 Td
(dental)Tj
2.6985 0 Td
(treatment,)Tj
4.3654 0 Td
(history)Tj
3.0047 0 Td
(of)Tj
1.0148 0 Td
(a)Tj
-36.51 -1.2983 Td
(bleeding)Tj
3.6283 0 Td
(disorder,)Tj
3.7984 0 Td
(any)Tj
1.6611 0 Td
(recent)Tj
2.7099 0 Td
(tooth)Tj
2.3584 0 Td
(extraction)Tj
4.2519 0 Td
(\(within)Tj
3.1578 0 Td
(1)Tj
0.6916 0 Td
(month\),)Tj
3.4866 0 Td
(history)Tj
3.0104 0 Td
(of)Tj
1.0148 0 Td
(oral)Tj
1.7745 0 Td
(candidiasis,)Tj
4.8642 0 Td
(or)Tj
-36.4079 -1.3039 Td
(an)Tj
1.2018 0 Td
(acute)Tj
2.3244 0 Td
(illness)Tj
2.6759 0 Td
(with)Tj
1.9956 0 Td
(fever,)Tj
2.4094 0 Td
(vomiting,)Tj
4.0706 0 Td
(diarrhea)Tj
3.5773 0 Td
(within)Tj
2.8119 0 Td
(5)Tj
0.6973 0 Td
(days)Tj
1.9956 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(study.)Tj
2.6192 0 Td
(We)Tj
1.6101 0 Td
(did)Tj
1.542 0 Td
(not)Tj
1.5704 0 Td
(include)Tj
-33.5846 -1.2983 Td
(incarcerated)Tj
5.1646 0 Td
(individuals)Tj
4.6488 0 Td
(or)Tj
1.0999 0 Td
(subjects)Tj
3.3788 0 Td
(living)Tj
2.4662 0 Td
(in)Tj
1.0374 0 Td
(group)Tj
2.6079 0 Td
(homes.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 125.9716 cm
BT
/F0 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Study)Tj
2.7543 0 Td
(measurement)Tj
6.0473 0 Td
(s)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 109.0204 cm
BT
/F6 1 Tf
1 TL
-0.012 Tc
0 0 Td
(For)Tj
1.5987 0 Td
(all)Tj
1.1225 0 Td
(subjects,)Tj
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